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    33844-21-2

    Catalog No. EBD40496

    CAS 33844-21-2

    Name 2-Nitro-4-methoxybenzoic acid

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    Basic Information

    Synonyms: 2-Nitro-4-methoxybenzoicacid 4-Methoxy-2-nitrobenzoicacid benzoicacid,4-methoxy-2-nitro-

    Molecular Formula: C8H7NO5

    Molecular Weight: 197.14

    MDL Number: MFCD04972109

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    4-Methoxy-2-nitrobenzoic acid is an organic compound featuring a benzoic acid core substituted with a methoxy group at the para position and a nitro group at the ortho position. It serves as a versatile and important chemical intermediate in organic synthesis. Its primary application is in the pharmaceutical industry as a key building block for the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates. For instance, it is a crucial precursor in the synthesis of certain benzodiazepine derivatives and other heterocyclic compounds with potential biological activity. The presence of both electron-donating (methoxy) and electron-withdrawing (nitro, carboxylic acid) groups makes it a valuable synthon for constructing more complex molecular architectures through sequential functional group transformations. As a commercially available fine chemical, it is utilized in research and development for medicinal chemistry. Standard safety precautions for handling nitroaromatic and carboxylic acid compounds should be observed in the laboratory.
    Physical Properties

    Melting Point: 196.5-200.5 °C(lit.)

    Boiling Point: 372.9 °C at 760 mmHg

    Flash Point: 179.3 °C

    Density: 1.43 g/cm3

    Storage: Keep Cold

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