9±-Fluorprednisolon acetat, CAS No. 338-98-7

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338-98-7

Catalog No. EBD15991

CAS 338-98-7

Name 9±-Fluorprednisolon acetat

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Basic Information

Synonyms: 9±-Fluorprednisolonacetat isoflupredone21-acetate (8xi,10xi,11beta,13xi,14xi,17xi)-9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-ylacetate (11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-ylacetate 9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-ylacetate Isoflupredone acetate 21-Acetoxy-9-Fluoro-11B,17-Dihydroxypregna-1,4-Diene-3,20-Dione

Molecular Formula: C23H29FO6

Molecular Weight: 420.47

MDL Number: MFCD00468096

Categories: Medicinal Chemistry > APIs and Their Salts > Immuno-modulators and Anti-inflammatory Drugs Medicinal Chemistry > APIs and Their Salts > Dermatological Drugs

Product Description:

9-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate, commonly known as 9-Fluoro Prednisolone Acetate, is a synthetic glucocorticoid. It is a fluorinated derivative of prednisolone acetate, where a fluorine atom is introduced at the 9-alpha position of the steroid nucleus. This structural modification typically enhances its anti-inflammatory potency and alters its metabolic profile compared to the parent compound. This compound is primarily used as an active pharmaceutical ingredient (API) in topical and injectable formulations. Its main applications are in the treatment of severe inflammatory and allergic conditions, particularly in dermatology for skin disorders such as eczema, psoriasis, and contact dermatitis. It exerts its effects by binding to glucocorticoid receptors, leading to the modulation of gene expression that suppresses inflammation and immune responses. As a potent corticosteroid, it requires careful medical supervision due to potential systemic side effects, especially with prolonged use or high doses. It is a key intermediate or final API in the synthesis of specialized corticosteroid medications.

Physical Properties

Boiling Point: 576.5 °C at 760 mmHg

Flash Point: 302.5 °C

Density: 1.32 g/cm3