2-Chloro-4-cyanopyridine, CAS No. 33252-30-1

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33252-30-1

Catalog No. EBD968998

CAS 33252-30-1

Name 2-Chloro-4-cyanopyridine

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Basic Information

Synonyms: 2-Chloro-4-cyanopyridine BUTTPARK43\57-01 4-CYANO-2-CHLOROPYRIDINE 2-CHLORO-4-PYRIDINECARBONITRILE 2-Chloro-Isonicotinonitrile 2-Chloroisonicotinonitrile

Molecular Formula: C6H3ClN2

Molecular Weight: 138.55

MDL Number: MFCD00174318

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Cyano Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2-Chloro-4-cyanopyridine is a heterocyclic building block featuring a pyridine ring substituted with a chlorine atom at the 2-position and a cyano group at the 4-position. This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of kinase inhibitors and other small-molecule drugs targeting neurological and inflammatory diseases. The chlorine atom acts as a leaving group for nucleophilic aromatic substitution, while the cyano group can be further transformed into carboxylic acids, amides, or amines, enabling diverse structural modifications. Additionally, it is widely used as a versatile synthetic building block in organic chemistry for constructing complex heterocyclic systems and functional materials.

Physical Properties

Melting Point: 69-73 °C(lit.)

Boiling Point: 104-106°C 15mm

Flash Point: 104-106°C/15mm

Density: 1.33 g/cm3

Analytical Data

Appearance: white or light yellow crystal