4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoic acid, CAS No. 33233-67-9

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33233-67-9

Catalog No. EBD897987

CAS 33233-67-9

Name 4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoic acid

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Basic Information

Synonyms: 4-[(tert-Butoxycarbonylamino)methyl]benzoicacid 4-{[(tert-Butoxycarbonyl)amino]methyl}benzoicacid benzoicacid,4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- 4-{[(tert-butoxycarbonyl)amino]methyl}benzoate Boc-4-Amb-OH 4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoicacid 4-tert-butoxycarbonylaminomethyl-benzoicacid 4-(((tert-butoxycarbonyl)amino)methyl)benzoicacid 4-[N-(tert-butoxycarbonyl)aminomethyl)benzoicacid 4-(tert-butyloxycarbonylamino)methylbenzoicacid 4-t-butoxycarbonylaminomethylbenzoicacid 4-carboxy-N-t-butoxycarbonylbenzylamine

Molecular Formula: C13H17NO4

Molecular Weight: 251.28

MDL Number: MFCD00228182

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

4-[(tert-Butoxycarbonylamino)methyl]benzoic acid is a bifunctional organic compound featuring both a carboxylic acid group and a tert-butoxycarbonyl (Boc)-protected amine group on a benzene ring. This structure makes it a versatile building block in organic synthesis, particularly in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of pharmaceutical compounds. The Boc-protected amine can be selectively deprotected under mild acidic conditions to generate a free amine, which can then be further functionalized. The carboxylic acid group allows for coupling reactions, such as amide bond formation. This compound is notably used in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs), including those targeting neurological disorders and other therapeutic areas. As a protected amino acid derivative, it is a valuable reagent in peptide mimetic and small molecule drug discovery. It is commercially available from suppliers specializing in fine chemicals and advanced intermediates for research and development.

Physical Properties

Melting Point: 164-168 °C

Boiling Point: 427.8 °C at 760 mmHg

Flash Point: 212.6 °C

Density: 1.178 g/cm3

Storage: Store at 0°C