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    33184-16-6

    Catalog No. EBD581131

    CAS 33184-16-6

    Name 5-Fluoro-2-methylbenzoic acid

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    Basic Information

    Synonyms: 2-Methyl-5-FluoroBenzoicAcid 2,3,4,5,6-pentafluorophenylalanine 5-fluoro-2-methylbenzoicacid 5-Fluoro-o-toluicacid(COOH=1)

    Molecular Formula: C8H7FO2

    Molecular Weight: 154.14

    MDL Number: MFCD00042294

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    5-Fluoro-2-methylbenzoic acid is an aromatic carboxylic acid derivative featuring a fluorine atom at the 5-position and a methyl group at the 2-position of the benzoic acid ring. This specific substitution pattern makes it a valuable and versatile building block in synthetic organic chemistry. Its primary and most significant application is in the pharmaceutical industry as a key intermediate. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates. For instance, it serves as a crucial precursor in the production of certain non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents where the 2-methyl-5-fluorobenzoic acid moiety is a core structural element. As a bifunctional synthon containing both a carboxylic acid group and a halogen (fluorine), it is amenable to a range of chemical transformations, including esterification, amidation, and nucleophilic aromatic substitution reactions. This reactivity profile solidifies its role not only as a specialized pharmaceutical intermediate but also as a useful organic synthesis building block for constructing more complex molecules in medicinal and materials chemistry research.
    Physical Properties

    Melting Point: 130-132 °C(lit.)

    Boiling Point: 262.1 °C at 760 mmHg

    Flash Point: 112.3 °C

    Density: 1.258 g/cm3

    Analytical Data

    Appearance: white to light yellow crystal powder

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