WITHANOLIDE A(P), CAS No. 32911-62-9

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32911-62-9

Catalog No. EBD3053740

CAS 32911-62-9

Name WITHANOLIDE A(P)

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Basic Information

Synonyms: (22R)-1-OXO-5,20,22-TRIHYDROXY-6WEI,7WEI-EPOXY-5WEI-ERGOSTA-2,24-DIENE-26-OICACIDWEI-LACTONE Ergosta-2,24-dien-26-oicacid,6,7-epoxy-5,20,22-trihydroxy-1-oxo-,d-lactone,(5a,6a,7a,22R)- 5a-Ergosta-2,24-dien-26-oicacid,6a,7a-epoxy-5,20,22-trihydroxy-1-oxo-,d-lactone,(22R)-(8CI) 6,7-Epoxy-1H-cyclopenta[a]phenanthrene,ergosta-2,24-dien-26-oicacidderiv. 5,20a-Dihydroxy-6a,7a-epoxy-1-oxowitha-2,24-dienolide 5a,20aF(R)-Dihydroxy-6a,7a-epoxy-1-oxowitha-2,24-dienolide WithanolideA WITHANIOL WITHANOLIDEA(P) WITHANOLIDEA(SH) WITHANOLIDEA(15MG) 5,20ALPHA-DIHYDROXY-6ALPHA,7ALPHA-EPOXY-1-OXOWITHA-2,24-DIENOLIDE (20R,22R)-5WEI,20-DIHYDROXY-6WEI,7WEI:22,26-DIEPOXYERGOSTA-2,24-DIENE-1,26-DIONE (22R)-6WEI,7WEI-EPOXY-5,20,22-TRIHYDROXY-1-OXO-5WEI-ERGOSTA-2,24-DIEN-26-OICACIDWEI-LACTONE

Molecular Formula: C28H38O6

Molecular Weight: 470.6

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Withaferin A is a steroidal lactone, specifically a withanolide, which is a major bioactive constituent isolated from the medicinal plant *Withania somnifera* (Ashwagandha). It is characterized by a C28 ergostane-type framework with a six-membered lactone ring (δ-lactone) attached at C-22 and C-26, and an α,β-unsaturated ketone moiety in ring A. Its primary research and potential therapeutic applications are centered on its potent biological activities. Withaferin A is extensively studied for its anti-cancer properties, demonstrating pro-apoptotic, anti-angiogenic, and anti-metastatic effects in various cancer cell lines and animal models. It is also investigated for its neuroprotective, anti-inflammatory, and immunomodulatory effects, linking it to potential applications in neurological and inflammatory disorders. The compound acts through multiple mechanisms, including modulation of key signaling pathways (e.g., NF-κB, STAT3), induction of oxidative stress, and disruption of cytoskeletal proteins like vimentin. Due to its natural origin and significant bioactivity profile, Withaferin A serves as a crucial reference standard, a lead compound for drug discovery, and a pharmacological tool in life science research. Its safety profile indicates it is generally well-tolerated at lower doses in studies but exhibits cytotoxicity at higher concentrations, which is the basis of its anti-cancer investigation.

Physical Properties