1-Bromo-2,4,5-trifluorobenzene, CAS No. 327-52-6

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327-52-6

Catalog No. EBD915002

CAS 327-52-6

Name 1-Bromo-2,4,5-trifluorobenzene

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Basic Information

Synonyms: 2,4,5-trifluorobromobenzene 2,4,5-trifluorobenzobromide 1-Bromo-2,4,5-trifluorobenzene 2,4,5-trifluorophenylbromide 2-bromo-1,4,5-trifluorobenzene

Molecular Formula: C6H2BrF3

Molecular Weight: 210.98

MDL Number: MFCD00000306

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

2,4,5-Trifluorobromobenzene is an organic compound characterized by a benzene ring substituted with bromine and three fluorine atoms at the 1, 2, 4, and 5 positions. It is a colorless to pale yellow liquid at room temperature and serves as a versatile and important halogenated aromatic building block in synthetic chemistry. Its primary application is as a key intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical industries. The bromine atom is an excellent site for further functionalization via cross-coupling reactions (e.g., Suzuki, Negishi, or Kumada couplings), while the fluorine atoms impart desirable properties such as metabolic stability, lipophilicity, and altered electronic characteristics to the final target compounds. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs) and advanced materials. This compound is moisture-sensitive and should be handled under inert atmosphere. It is also a lachrymator and can cause skin and eye irritation, requiring appropriate safety precautions during use.

Physical Properties

Melting Point: −19 °C(lit.)

Boiling Point: 144 °C(lit.)

Flash Point: 56 °C

Density: 1.802 g/mL at 25 °C(lit.)

Solubility: insoluble

Refractivity: n20/D 1.485(lit.)

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 1993C