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    32511-34-5

    Catalog No. EBD2637924

    CAS 32511-34-5

    Name endo-(1R)-2-amino-1,7,7-trimethylbicyclo[2.2.1]heptane

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    Basic Information

    Synonyms: 3-norbornylamine endo-(1R)-2-amino-1,7,7-trimethylbicyclo[2.2.1]heptane R(+)-bornylamine (R)-(+)-Bornylamine (1R,2S,4R)-born-2-ylamine 1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine (1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine

    Molecular Formula: C10H19N

    Molecular Weight: 153.26

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-(+)-Camphorsultam, also known as (R)-(+)-10-Camphorsulfonamide or (R)-(+)-10-Camphorsultam, is a chiral bicyclic compound derived from camphor. It is a white to off-white crystalline solid with the molecular formula C10H17NO2S and a CAS number of 32511-34-5. This compound is a key member of the camphorsultam family, which are highly valuable chiral auxiliaries and resolving agents in asymmetric synthesis. Its primary and most significant application is in the field of pharmaceutical chemistry as a versatile chiral auxiliary. The rigid, well-defined chiral environment of the camphor skeleton allows (R)-(+)-Camphorsultam to induce high stereoselectivity in a variety of reactions, including alkylations, aldol reactions, and Diels-Alder reactions. It is extensively used in the synthesis of enantiomerically pure intermediates for active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the nervous system, cardiovascular diseases, and other therapeutic areas. Its role is crucial for constructing complex chiral molecules with the desired biological activity. Due to its fundamental utility as a building block for introducing chirality, it is also considered a specialized organic synthesis building block. The compound is typically handled under inert atmosphere and stored in a cool, dry place. It is a staple reagent in research and process chemistry laboratories focused on asymmetric methodology and the production of chiral drugs.
    Physical Properties

    Melting Point: 160-163 °C(lit.)

    Boiling Point: 189 ºC

    Flash Point: 48 ºC

    Density: 0.923

    Storage: 2-8°C

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