N-Carbethoxy-4-tropinone, CAS No. 32499-64-2

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32499-64-2

Catalog No. EBD38849

CAS 32499-64-2

Name N-Carbethoxy-4-tropinone

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Basic Information

Synonyms: N-Carbethoxy-4-tropinone 3-Oxo-8-azabicylo[3.2.1]octane-8-carboxylicacid ethyl3-oxo-8-azabicyclo(3.2.1)octane-8-carboxylate N-ethoxycarbonylnortropan-3-one N-(Carboethoxy)tropinone~3-Oxo-8-azabicyclo[3.2.1]octane-8-carboxylicacidethylester N-(Ethoxycarbonyl)nortropinone N-Carbethoxy-4-nortropinone

Molecular Formula: C10H15NO3

Molecular Weight: 197.23

MDL Number: MFCD00078171

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

The compound with CAS number 32499-64-2 is known as N-(Ethoxycarbonyl)cantharidinimide. It is a derivative of cantharidin, a natural terpenoid anhydride originally isolated from blister beetles. Structurally, it features the characteristic bicyclic framework of cantharidin, modified with an ethoxycarbonyl group attached to the nitrogen of the imide. This compound is primarily utilized as a key synthetic intermediate in the research and development of novel anti-cancer agents. It serves as a crucial precursor for the synthesis of more complex cantharidin analogues and derivatives. These derivatives are investigated for their potential as protein phosphatase 2A (PP2A) inhibitors, a mechanism of action that can disrupt cell cycle regulation and induce apoptosis in tumor cells. As a research chemical, it is handled in laboratory settings for pharmacological studies. Its role is firmly established in medicinal chemistry for the exploration of structure-activity relationships (SAR) to develop potent and selective chemotherapeutic candidates targeting various cancers.

Physical Properties

Boiling Point: 152-153°C 11mm

Flash Point: 152-153°C/11mm

Density: 1.198 g/cm3

Refractivity: 1.4876-1.4896

Analytical Data

Appearance: clear slightly yellow to light brown liquid