4-amino-5-chloro-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one, CAS No. 32387-56-7

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32387-56-7

Catalog No. EBD201269

CAS 32387-56-7

Name 4-amino-5-chloro-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

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Basic Information

Synonyms: 4-amino-5-chloro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one 4-amino-5-chloro-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 5-chloro-2'-deoxycytidine 2'-Deoxy-5-chlorocytidine 5-Chlorodeoxycytidine NSC371331 Cytidine,5-chloro-2'-deoxy- 4-amino-5-chloro-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one Cytochlor

Molecular Formula: C9H12ClN3O4

Molecular Weight: 261.66

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

5-Chloro-2'-deoxycytidine is a halogenated nucleoside analog. Its chemical structure consists of a 2'-deoxyribose sugar linked to a cytosine base that has been substituted with a chlorine atom at the 5-position. This modification imparts distinct chemical and biological properties compared to the natural nucleoside. This compound serves as a key intermediate in the synthesis of more complex nucleoside analogs with potential therapeutic applications. It is particularly valuable in medicinal chemistry research for the development of antiviral and anticancer agents, as modifications at the 5-position of the pyrimidine ring are a common strategy to alter base-pairing properties and inhibit viral or cellular DNA polymerases. As a modified nucleoside, it falls under the category of nucleoside chemistry building blocks. Its primary utility lies in research and development settings for constructing oligonucleotides or as a precursor for prodrugs, rather than as a direct active pharmaceutical ingredient (API).

Physical Properties

Boiling Point: 497.9°Cat760mmHg

Flash Point: 254.9°C

Density: 1.86g/cm3