Melphalan hydrochloride, CAS No. 3223-07-2

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3223-07-2

Catalog No. EBD25175

CAS 3223-07-2

Name Melphalan hydrochloride

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Basic Information

Synonyms: L-Phenylalaninemustardhydrochloride (S)-3-[4-[Bis(2-chloroethyl)amino]phenyl]alaninehydrochloride 2-{4-[bis(2-chloroethyl)amino]phenyl}-1-carboxyethanaminiumchloride 4-[bis(2-chloroethyl)amino]-L-phenylalaninehydrochloride L-Sarcolysinehydrochloride Melphalanhydrochloride

Molecular Formula: C13H19Cl3N2O2

Molecular Weight: 341.66

Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Melphalan hydrochloride is the hydrochloride salt of melphalan, a bifunctional alkylating agent belonging to the nitrogen mustard class. Its chemical name is 4-[bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride. This compound is a white to off-white crystalline powder. As an active pharmaceutical ingredient (API), melphalan hydrochloride is a chemotherapeutic agent primarily used in the treatment of multiple myeloma and ovarian carcinoma. It functions by cross-linking DNA strands through alkylation, thereby inhibiting DNA replication and RNA transcription, which leads to cell death, particularly in rapidly dividing cells. In addition to its direct therapeutic use, melphalan and its related impurities are critical for quality control in pharmaceutical manufacturing. Reference standards of melphalan hydrochloride are essential for analytical methods development, validation, and routine testing to ensure drug purity, safety, and efficacy, making it also relevant as a pharmaceutical impurity reference standard.

Physical Properties

Boiling Point: 473.1°Cat760mmHg

Flash Point: 239.9°C

Safety Information

Packing Level: II

Hazard Category: 6.1

Transport Codes: 2811