(S)-1-Boc-3-hydroxymethylpiperazine, CAS No. 314741-40-7

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

314741-40-7

Catalog No. EBD20727

CAS 314741-40-7

Name (S)-1-Boc-3-hydroxymethylpiperazine

Get Quote

Basic Information

Synonyms: (S)-1-Boc-3-Hydroxymethyl-piperazine tert-butyl(3S)-3-(hydroxymethyl)piperazine-1-carboxylate (S)-4-N-Boc-2-(Hydroxymethyl)Piperazine (S)-tert-Butyl3-(hydroxymethyl)piperazine-1-carboxylate (S)-1-Boc-3-hydroxymethylpiperazine

Molecular Formula: C10H20N2O3

Molecular Weight: 216.28

MDL Number: MFCD05863889

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-Boc-3-hydroxymethylpiperazine is a chiral piperazine derivative featuring a hydroxymethyl group at the 3-position and a tert-butoxycarbonyl (Boc) protecting group on the nitrogen. This compound serves as a versatile and crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of various active pharmaceutical ingredients (APIs). The chiral piperazine scaffold is a privileged structure found in numerous drugs, particularly those targeting the central nervous system and as kinase inhibitors. The Boc group provides orthogonal protection for the secondary amine, while the hydroxymethyl group offers a handle for further functionalization, making it a pivotal starting material for constructing complex drug molecules. This intermediate is of high importance in medicinal chemistry for the development of novel therapeutic agents, underscoring its value in the synthesis of chirally pure compounds.

Physical Properties

Boiling Point: 322.9 °C at 760 mmHg

Flash Point: 149.1 °C

Density: 1.085 g/cm3