2 - Chloro - 4,6 - dimethoxy - 1,3,5 - triazine, CAS No. 3140-73-6

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3140-73-6

Catalog No. EBD12312

CAS 3140-73-6

Name 2 - Chloro - 4,6 - dimethoxy - 1,3,5 - triazine

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Basic Information

Synonyms: AKOS89995 Chlorodimethoxytriazine 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE(CDMT) 2-CHLORO-4,6-DIMETHOXY-TRIAZINE 2-CHLORO4,6-DIMETHOX1,3,5-TRIAZINE 2-Chloro-4,6-Dimetoxy-1,3,5-Triazine； 2-Chloro-4,6-dimethoxy-[1,3,5]triazine 1,3,5-triazine,2-chloro-4,6-dimethoxy- 2-Chloro-4,6-dimethoxy-1,3,5-triazine 2,4-dimethoxy-6-chloro-s-triazine 2-chloro-4,6-dimethoxy-s-triazine 4,6-dimethoxy-2-chloro-s-triazine 6-chloro-2,4-dimethoxy-s-triazine 2,4-dimethoxy-6-chloro-1,3,5-triazine s-triazine,2-chloro-4,6-dimethoxy-(6ci,7ci,8ci)

Molecular Formula: C5H6ClN3O2

Molecular Weight: 175.57

MDL Number: MFCD00075607

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers Synthetic Chemistry > Basic Synthetic Reagents > Condensation Reagents

Product Description:

2-Chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) is a triazine-based compound with the molecular formula C5H6ClN3O2. It is widely recognized as a highly efficient coupling reagent in peptide synthesis, functioning as an activator for carboxylic acids to form amides or esters under mild conditions. Its mechanism involves the formation of an active ester intermediate, which reacts with amines or alcohols to yield the desired product with minimal racemization. Beyond its role as a coupling agent, CDMT serves as a versatile synthetic building block in medicinal chemistry, particularly for constructing heterocyclic scaffolds. It is employed in the preparation of pharmaceutical intermediates, agrochemicals, and functional materials due to its triazine core, which can undergo nucleophilic substitution reactions. The compound is valued for its stability, low toxicity, and compatibility with a wide range of solvents, making it a standard reagent in both research and industrial-scale organic synthesis.

Physical Properties

Melting Point: 71-74 °C(lit.)

Boiling Point: 99-100 °C (1 mmHg)

Flash Point: 99-100°C/1mm

Density: 1.36 g/cm3

Solubility: insoluble