(4-Methoxy-2-(trifluoromethyl)phenyl)boronic acid, CAS No. 313546-16-6

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313546-16-6

Catalog No. EBD22104

CAS 313546-16-6

Name (4-Methoxy-2-(trifluoromethyl)phenyl)boronic acid

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Basic Information

Synonyms: 4-Methoxy-2-(trifluoromethyl)benzeneboronicacid [4-Methoxy-2-(trifluoromethyl)phenyl]boronicacid Boronicacid,B-[4-methoxy-2-(trifluoromethyl)phenyl]- 4-Methoxy-2-(Trifluoromethyl)PhenylboronicAcid (4-Methoxy-2-(trifluoromethyl)phenyl)boronicacid

Molecular Formula: C8H8BF3O3

Molecular Weight: 219.95

MDL Number: MFCD03095346

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

4-Methoxy-2-(trifluoromethyl)phenylboronic acid is an organoboron compound featuring a phenyl ring substituted with a methoxy group at the para position and a trifluoromethyl group at the ortho position, bearing a boronic acid functional group. It is a white to off-white crystalline powder commonly used as a key synthetic building block. This compound is primarily employed in Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing biaryl and heterobiaryl structures in medicinal chemistry. Its specific substitution pattern makes it a valuable intermediate in the synthesis of more complex molecules, particularly in pharmaceutical research for developing potential drug candidates. The trifluoromethyl group is a common pharmacophore that can enhance metabolic stability and lipophilicity. As a boronic acid derivative, it requires careful handling and storage under inert conditions to prevent protodeboronation and maintain reactivity. It is a standard reagent available from major chemical suppliers for use in organic synthesis and drug discovery programs.

Physical Properties

Melting Point: 168-172 °C

Boiling Point: 314.12 °C at 760 mmHg

Flash Point: 143.775 °C

Density: 1.361 g/cm3

Storage: 2-8°C