8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-one, CAS No. 31251-41-9

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

31251-41-9

Catalog No. EBD6649

CAS 31251-41-9

Name 8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-one

Get Quote

Basic Information

Synonyms: 8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-one 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-one 11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one,8-chloro-5,6-dihydro- 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Molecular Formula: C14H10ClNO

Molecular Weight: 243.69

MDL Number: MFCD00800222

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a complex tricyclic organic compound featuring a fused benzocycloheptapyridinone core structure with a chlorine substituent. It is a key synthetic intermediate in the preparation of loratadine, a widely used second-generation antihistamine, and its active metabolite, desloratadine. This compound serves as a crucial advanced building block in the multi-step synthesis of loratadine. The synthetic route typically involves the cyclization and subsequent functionalization of this intermediate to construct the final drug molecule. Its primary and well-defined industrial application is in the pharmaceutical manufacturing sector for the production of anti-allergy medications. As a specialized pharmaceutical intermediate, it is not a commodity chemical and is primarily handled in controlled industrial or research settings for synthetic purposes. Proper handling procedures should be followed due to its status as a fine chemical intermediate.

Physical Properties

Melting Point: 90-92°C

Boiling Point: 433.614 °C at 760 mmHg

Flash Point: 216.042 °C

Density: 1.314 g/cm3

Analytical Data

Appearance: Yellow solid