(R)-1-Phenylpropan-1-amine, CAS No. 3082-64-2

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3082-64-2

Catalog No. EBD2219891

CAS 3082-64-2

Name (R)-1-Phenylpropan-1-amine

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Basic Information

Synonyms: (R)-1-Phenylpropan-1-amine (R)-(+)-1-phenylpropylamine (R)-(+)-1-Amino-1-phenylpropane (R)-(+)-alpha-Ethylbenzylamine (1R)-1-phenylpropan-1-amine (1S)-1-phenylpropan-1-amine R(+)-a-ethylbenzylamine

Molecular Formula: C9H13N

Molecular Weight: 135.21

MDL Number: MFCD00083057

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-(+)-1-Phenylpropylamine is a chiral primary amine featuring a phenyl group and a propyl chain. It is a valuable chiral building block and resolving agent in organic synthesis. Its primary application is as a chiral intermediate in the pharmaceutical industry. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including certain antidepressants and other central nervous system (CNS) agents. The compound serves as a key precursor for introducing the chiral 1-phenylpropylamine moiety into target molecules. Furthermore, it is employed as a chiral resolving agent for the separation of racemic mixtures of carboxylic acids through diastereomeric salt formation. The compound should be handled with care as it is a strong organic base and may cause skin and eye irritation. It is typically stored under an inert atmosphere due to its sensitivity.

Physical Properties

Melting Point: -69°C

Boiling Point: 205°C

Flash Point: 77 °C

Density: 0.940 g/mL at 20 °C(lit.)

Refractivity: n20/D 1.520

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 2735PSN1