2-amino-2,2-diphenylacetic acid, CAS No. 3060-50-2

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3060-50-2

Catalog No. EBD77348

CAS 3060-50-2

Name 2-amino-2,2-diphenylacetic acid

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Basic Information

Synonyms: 2-amino-2,2-diphenylaceticacid amino(diphenyl)aceticacid α,α-Diphenylglycine Alpha,Alpha-Diphenylglycine alpha-aminodiphenylaceticacid benzeneaceticacid,a-amino-a-phenyl- 2,2-diphenylglycine a,a-diphenylglycine a-aminodiphenylaceticacid glycine,2,2-diphenyl-(6ci,7ci,8ci) 2-amino-2,2-diphenyl-aceticacid

Molecular Formula: C14H13NO2

Molecular Weight: 227.26

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2,2'-Diphenylglycine is an organic compound featuring a central glycine moiety substituted with two phenyl groups at the alpha carbon. It is a white to off-white crystalline powder. This structure makes it a chiral amino acid derivative, often existing as a racemic mixture unless specifically resolved. This compound serves as a key chiral intermediate in pharmaceutical synthesis. Its primary application is in the production of penicillins and cephalosporins, where it acts as a crucial building block for constructing the beta-lactam core structure. The diphenyl substitution pattern is significant for imparting specific steric and electronic properties required for biological activity and synthetic manipulation in antibiotic development. As a bifunctional molecule containing both carboxylic acid and amine groups, it is also utilized in organic synthesis as a specialty building block for constructing more complex molecules, particularly those requiring chiral amino acid motifs. It finds use in peptide mimetics and as a ligand precursor in coordination chemistry.

Physical Properties

Melting Point: 245-247 °C (dec.)(lit.)

Boiling Point: 383.5 °C at 760 mmHg

Flash Point: 185.7 °C

Density: 1.231 g/cm3

Analytical Data

Appearance: white powder