2,4-Dichloro-5-pyrimidinecarbonyl chloride, CAS No. 2972-52-3

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

2972-52-3

Catalog No. EBD16609

CAS 2972-52-3

Name 2,4-Dichloro-5-pyrimidinecarbonyl chloride

Get Quote

Basic Information

Synonyms: 2,4-Dichloropyrimidine-5-carbonylchloride 5-pyrimidinecarbonylchloride,2,4-dichloro- 2,4-Dichloro-5-pyrimidinecarbonylchloride 2,4-dichloropyrimidine-5-carbonyl chloride

Molecular Formula: C5HCl3N2O

Molecular Weight: 211.43

MDL Number: MFCD09742432

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

2,4-Dichloro-5-pyrimidinecarbonyl chloride is a versatile heterocyclic building block characterized by a pyrimidine ring substituted with two chlorine atoms and a reactive acid chloride group. This bifunctional structure makes it a key intermediate in organic synthesis, particularly for the construction of more complex molecules. Its primary and most significant application is in the pharmaceutical industry as a crucial intermediate for the synthesis of various active pharmaceutical ingredients (APIs). It serves as a core scaffold for the production of dihydrofolate reductase (DHFR) inhibitors, a class of compounds with important therapeutic applications. Notably, it is a key precursor in the synthesis of trimethoprim, a widely used antibiotic, and related analogs. The reactive acid chloride group allows for facile amide bond formation, enabling the introduction of diverse amine-containing side chains to modulate biological activity. Due to its high reactivity, it must be handled under inert conditions (e.g., nitrogen atmosphere) and is typically stored at low temperatures (e.g., 2-8°C). It is moisture-sensitive and hydrolyzes readily.

Physical Properties

Boiling Point: 304.32 °C at 760 mmHg

Flash Point: 93 °C

Density: 1.645 g/mL at 25 °C

Refractivity: n20/D 1.586

Safety Information

Packing Level: III

Hazard Category: 8

Transport Codes: 3265