D-Glucose,2-deoxy-2-fluoro-, CAS No. 29702-43-0

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29702-43-0

Catalog No. EBD2224346

CAS 29702-43-0

Name D-Glucose,2-deoxy-2-fluoro-

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Basic Information

Synonyms: D-Glucose,2-deoxy-2-fluoro- 2-fluoro-2-deoxy-D-glucopyranose 2-deoxy-2-fluorohexopyranose 2-fluoro-2-deoxy-D-glucose,mixtureofanomers 2-Deoxy-fluoro-glucose D-Glucopyranose,2-deoxy-2-fluoro-FDG

Molecular Formula: C6H11FO5

Molecular Weight: 182.15

MDL Number: MFCD00077527

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Drug Impurities and Reference Standards > Drug Metabolite References

Product Description:

2-Deoxy-2-fluoro-D-glucose (2-FDG), CAS 29702-43-0, is a glucose analog where the hydroxyl group at the C-2 position is replaced by a fluorine atom. This structural modification significantly alters its metabolic pathway compared to natural glucose. Its primary and most critical application is as a precursor for the synthesis of the positron emission tomography (PET) imaging agent, 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG). [¹⁸F]FDG is the most widely used radiopharmaceutical in clinical oncology, neurology, and cardiology for diagnosing and monitoring diseases like cancer, epilepsy, and myocardial viability. The non-radioactive 2-FDG serves as a crucial reference standard, cold standard, and impurity control material in the quality control and validation of [¹⁸F]FDG production and synthesis processes. Due to its role as a key intermediate and reference compound specifically for a major diagnostic radiopharmaceutical, it is classified under life science reagents and drug reference standards. It is not a general-purpose synthetic building block.

Physical Properties

Melting Point: 170 °C

Boiling Point: 478.4 °C at 760 mmHg

Flash Point: 243.1 °C

Density: 1.494 g/cm3

Storage: 2-8°C