Boc-L-alpha-phenylglycine, CAS No. 2900-27-8

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2900-27-8

Catalog No. EBD2156820

CAS 2900-27-8

Name Boc-L-alpha-phenylglycine

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Basic Information

Synonyms: Boc-Phg-OH~N-(tert-Butoxycarbonyl)-L-phenylglycine Boc-Phg-OH N-alpha-tert-Butoxycarbonyl-L-phenylglycine Boc-L-phenylglycine [(tert-butoxycarbonyl)amino](phenyl)aceticacid (2R)-[(tert-butoxycarbonyl)amino](phenyl)ethanoicacid (2S)-[(tert-butoxycarbonyl)amino](phenyl)ethanoicacid Boc-L-Phg-OH Boc-L-alpha-phenylglycine N-Boc-L-phenylglycine N-boc-L-alpha-phenylglycine (s)-n-boc-2-phenylglycine (s)-n-boc-a-amino-a-phenylaceticacid (tert-butoxycarbonyl)-l-phenylglycine n-tert-butoxycarbonyl-l-phenylglycine n-tert-butoxycarbonyl-l-a-phenylglycine (s)-n-(tert-butoxycarbonyl)phenylglycine (s)-n-tert-butoxycarbonyl-2-phenylglycine

Molecular Formula: C13H17NO4

Molecular Weight: 251.28

MDL Number: MFCD00062043

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-L-phenylglycine is a protected amino acid derivative featuring a phenylglycine backbone with a tert-butoxycarbonyl (Boc) group on the nitrogen atom. It is a white to off-white crystalline powder and serves as a crucial chiral building block in organic synthesis. Its primary application is in the pharmaceutical industry as a key intermediate for the synthesis of various active pharmaceutical ingredients (APIs). It is notably used in the production of β-lactam antibiotics, such as certain cephalosporins, and other peptide-based drugs where the incorporation of the phenylglycine moiety is essential for biological activity. The Boc protecting group facilitates selective reactions and is readily removable under mild acidic conditions. This compound is a versatile reagent in peptide chemistry and medicinal chemistry research. It is commercially available from numerous fine chemical suppliers and is typically handled under standard laboratory conditions, requiring storage in a cool, dry place.

Physical Properties

Melting Point: 88-91 °C

Boiling Point: 407.2 °C at 760 mmHg

Flash Point: 200.1 °C

Density: 1.182 g/cm3

Refractivity: 142 ° (C=1, EtOH)

Storage: Store at RT.