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    28978-07-6

    Catalog No. EBD3049348

    CAS 28978-07-6

    Name 7-OXABICYCLO[4.1.0]HEPTANE-2-PROPANOIC ACID, .ALPHA.-AMINO-5-OXO-, (1R-(1.ALPHA.,2.ALPHA.(S*),6.ALPHA.))-

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    Basic Information

    Synonyms: ANTICAPSIN (1R,6R,WEIS)-WEI-AMINO-5-OXO-7-OXABICYCLO[4.1.0]HEPTANE-2WEI-PROPIONICACID 7-OXABICYCLO[4.1.0]HEPTANE-2-PROPANOICACID,.ALPHA.-AMINO-5-OXO-,(1R-(1.ALPHA.,2.ALPHA.(S*),6.ALPHA.))- 3-[(1R,2R,6R)-5-oxo-7-oxabicyclo[4.1.0]hept-2-yl]-L-alanine 7-oxabicyclo[4.1.0]heptane-2-propanoicacid,alpha-amino-5-oxo-,(alphaS,1R,2R,6R)-

    Molecular Formula: C9H13NO4

    Molecular Weight: 199.2

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

    Product Description:
    7-Oxabicyclo[4.1.0]heptane-2-propanoic acid, α-amino-5-oxo-, (1R-(1α,2α(S*),6α))- is a complex bicyclic amino acid derivative. Its structure features a fused oxabicyclo[4.1.0]heptane (oxirane-fused cyclohexane) core, an amino group, and a propanoic acid side chain, making it a conformationally constrained, non-proteinogenic amino acid analog. This compound is primarily utilized as a key chiral intermediate or building block in pharmaceutical research and synthesis. Its rigid, polycyclic scaffold is valuable for constructing novel bioactive molecules, particularly in the development of protease inhibitors and other therapeutic agents that target enzymes or receptors where conformational restriction is crucial for activity and selectivity. The presence of both amino and carboxylic acid functionalities allows for its incorporation into peptides or peptidomimetics. As a specialized synthetic intermediate, it falls under the category of heterocyclic intermediates due to its oxirane and bicyclic framework. Its structural relationship to amino acids also classifies it within the broader scope of amino acid derivatives used in life science research.
    Physical Properties

    Boiling Point: 415.9°C at 760 mmHg

    Flash Point: 205.3°C

    Density: 1.368g/cm3

    mg g kg ml l t