trans-2,5-Dimethylpiperazine, CAS No. 2815-34-1

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2815-34-1

Catalog No. EBD2219857

CAS 2815-34-1

Name trans-2,5-Dimethylpiperazine

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Basic Information

Synonyms: (2s,5r)-2,5-dimethyl-piperazine trans-2,5-dimethylpyrazine trans-1,2-dimethylpiperazine trans-2,5-dimethylpiperzine trans-2,5-dimethylpiperazine,98% 2,5-dimethylpiperazine piperazine,2,5-dimethyl-,(2r,5s)- trans-2,5-Dimethylpiperazine 2,5-Dimethylpiperazine(trans) (2R,5S)-2,5-dimethylpiperazine (2R,5S)-2,5-dimethylpiperazinediium (2R,5R)-2,5-dimethylpiperazinediium (2S,5S)-2,5-dimethylpiperazinediium (2R,5S)-2,5-Dimethyl-piperazine

Molecular Formula: C6H14N2

Molecular Weight: 114.19

MDL Number: MFCD00070516

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Trans-2,5-Dimethylpiperazine is a cyclic diamine compound featuring a piperazine ring with two methyl groups in the trans configuration at the 2 and 5 positions. It is a solid at room temperature and serves as a versatile chiral building block and organic base in chemical synthesis. Its primary industrial application is as a key pharmaceutical intermediate. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including certain antibiotics and other therapeutic agents. The rigid, chiral structure of the trans isomer makes it valuable for constructing molecules with specific three-dimensional configurations required for biological activity. Beyond its role in drug synthesis, trans-2,5-dimethylpiperazine is also employed as a ligand in coordination chemistry and as a component in the preparation of polymers and corrosion inhibitors. Due to its basicity and bifunctional nature, it finds utility in diverse organic transformations and material science applications.

Physical Properties

Melting Point: 115-118 °C(lit.)

Boiling Point: 162-165 °C(lit.)

Flash Point: 38 °C

Density: 0.53

Solubility: 50 g/100 mL (20°C)

Storage: Flammables area

Safety Information

Packing Level: II

Hazard Category: 6.1(4.1)

Transport Codes: 2926