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    279262-09-8

    Catalog No. EBD211158

    CAS 279262-09-8

    Name 3-Fluoro-4-morpholinophenylboronic Acid

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    Basic Information

    Synonyms: (3-fluoro-4-morpholino-phenyl)boronicacid [3-Fluoro-4-(morpholin-4-yl)phenyl]boronicacid Boronicacid,B-[3-fluoro-4-(4-morpholinyl)phenyl]- 3-Fluoro-4-morpholinophenylboronicAcid

    Molecular Formula: C10H13BFNO3

    Molecular Weight: 225.03

    MDL Number: MFCD16883060

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    3-Fluoro-4-(4-morpholinyl)phenylboronic acid is an organoboron compound featuring a phenylboronic acid core substituted with a fluorine atom and a morpholine group at the meta and para positions, respectively. This specific substitution pattern makes it a valuable arylboronic acid building block in synthetic chemistry. Its primary application is in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing biaryl and heterobiaryl structures. The boronic acid group acts as the key coupling partner with aryl halides or triflates in the presence of a palladium catalyst. The fluorine atom can serve as a synthetic handle for further functionalization, while the morpholine moiety introduces nitrogen and oxygen heteroatoms, which are common pharmacophores in medicinal chemistry. Consequently, this compound is frequently employed in the synthesis of complex molecules for pharmaceutical research and development, particularly as an intermediate in the discovery of drug candidates targeting various diseases. As a specialty boronic acid, it is typically handled under inert atmosphere to prevent protodeboronation and is considered an air- and moisture-sensitive reagent.
    Physical Properties

    Boiling Point: 420.416°C at 760 mmHg

    Flash Point: 208.061°C

    Density: 1.314g/cm3

    mg g kg ml l t