trans-1-amino-4-cyclohexanol, CAS No. 27489-62-9

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27489-62-9

Catalog No. EBD2204054

CAS 27489-62-9

Name trans-1-amino-4-cyclohexanol

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Basic Information

Synonyms: (1R,4R)-4-aminocyclohexanol trans-1-amino-4-cyclohexanol trans-4-Aminocyclohexanol Timtec-bbsbb005825 trans-4-amino-1-hydroxycyclohexane aminocyclohexanol(trans-4) auroraka-7506 trans-4-aminocyclohexan-1-ol 4-transaminocyclohexanol trans-4-hydroxycyclohexylamine 1-(1,3-dioxolan-2-yl)methanamine Aminocyclohexanol,trans-4- -aminocyclohexanol cyclohexanol,4-amino-,trans-

Molecular Formula: C6H13NO

Molecular Weight: 115.17

MDL Number: MFCD00067698

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Trans-4-Aminocyclohexanol is an organic compound featuring both an amino group and a hydroxyl group on a cyclohexane ring in a trans configuration. It is a white to off-white crystalline powder. This compound is a versatile chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of various active pharmaceutical ingredients (APIs). Notably, it serves as a crucial precursor in the synthesis of certain antibacterial agents, such as the quinolone antibiotic trovafloxacin. The trans-1,4-substituted cyclohexane scaffold is a privileged structure in medicinal chemistry, contributing to the desired pharmacological properties of the final drug molecules. Beyond its role in specific drug syntheses, trans-4-aminocyclohexanol is also utilized in the preparation of other fine chemicals and as a ligand or modifier in certain catalytic systems. It is commercially available from several chemical suppliers for research and development purposes.

Physical Properties

Melting Point: 108-113°C

Boiling Point: 127 °C / 14mmHg

Flash Point: 75.4 °C

Density: 1.037 g/cm3

Solubility: soluble in chloroform and other organic solvents