[3aR-(3a±,4±,6±,6a±)]-2-[[6-amino-2,2-dimethyl-tetrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-ethanol, CAS No. 274693-55-9

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

274693-55-9

Catalog No. EBD328765

CAS 274693-55-9

Name [3aR-(3a±,4±,6±,6a±)]-2-[[6-amino-2,2-dimethyl-tetrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-ethanol

Get Quote

Basic Information

Synonyms: [3aR-(3a±,4±,6±,6a±)]-2-[[6-amino-2,2-dimethyl-tetrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-ethanol (3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-amine 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol 2-{[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy}ethanol 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol Ethanol,2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- 2-{[(3Ar,4S,6R,6As)-6-Amino-2,2-Dimethyltetrahydro-3Ah-Cyclopenta[D][1,3]-Dioxol-4-Yl]Oxy}-1-Ethol

Molecular Formula: C10H19NO4

Molecular Weight: 217.26

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

This compound, with the CAS number 274693-55-9 and the chemical name 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta[d][1,3]dioxol-4-yl]oxy]ethanol, is a protected nucleoside derivative. Its structure features a cyclopentane ring fused with a dioxolane protecting group, an amino group, and an ethoxyethanol side chain, indicating it is a modified ribose or related sugar scaffold. Its primary application is as a key synthetic intermediate in the preparation of nucleoside analogs and modified oligonucleotides for pharmaceutical research. Specifically, it serves as a crucial building block for the synthesis of sofosbuvir (PSI-7977), a direct-acting antiviral nucleotide prodrug used to treat hepatitis C virus (HCV) infection. The protected amino and hydroxyl groups allow for selective functionalization to construct the active pharmaceutical ingredient. As a high-value specialty chemical, it is primarily used in medicinal chemistry and process development for antiviral drugs. Its synthesis and handling require expertise due to its chiral nature and role in producing complex therapeutic agents.

Physical Properties

Boiling Point: 338.144 °C at 760 mmHg

Flash Point: 158.304 °C

Density: 1.21 g/cm3