Ethyl 2-(pyridin-2-yl)acetate, CAS No. 2739-98-2

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2739-98-2

Catalog No. EBD37819

CAS 2739-98-2

Name Ethyl 2-(pyridin-2-yl)acetate

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Basic Information

Synonyms: Ethyl2-(pyridin-2-yl)acetate 2-pyridineaceticacidethylester 2-pyridylaceticacidethylester ethylpyridine-2-acetate ethyl2-pyridin-2-ylacetate ethyl2-pyridineacetate ethyl2-pyridylacetate pyridine-2-aceticacidethylester ethyl2-pyridylacetate,98% ethylpyridin-2-ylacetate

Molecular Formula: C9H11NO2

Molecular Weight: 165.19

MDL Number: MFCD00006359

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Ethyl 2-(pyridin-2-yl)acetate is an organic compound featuring a pyridine ring linked to an ethyl acetate group via a methylene bridge. It serves as a versatile and important heterocyclic building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key synthetic intermediate in the preparation of various bioactive molecules. For instance, it is a crucial precursor in the synthesis of pralidoxime (2-PAM), a well-known cholinesterase reactivator used as an antidote for poisoning by organophosphorus nerve agents and pesticides. The ester group can be readily hydrolyzed to the corresponding acid or undergo further transformations, making it a valuable starting material for constructing more complex pyridine-containing structures with potential pharmacological activity. While its most defined use is in pharmaceutical intermediate synthesis, its structural features also make it a useful reagent in general organic chemistry research for introducing the 2-pyridylacetic acid moiety into target molecules.

Physical Properties

Boiling Point: 70 °C/0.05 mmHg(lit.)

Flash Point: 110 °C

Density: 1.084 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.497(lit.)

Analytical Data

Appearance: clear yellow liquid