Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    270063-48-4

    Catalog No. EBD2328336

    CAS 270063-48-4

    Name Boc-(S)-3-amino-4-(2,4-dichlorophenyl)butyric acid

    Get Quote
    Basic Information

    Synonyms: Boc-(S)-3-amino-4-(2,4-dichlorophenyl)butyricacid Boc-(S)-3-amino-4-(2,4-dichloro-phenyl)-butyricacid (3S)-3-[(tert-butoxycarbonyl)amino]-4-(2,4-dichlorophenyl)butanoicacid

    Molecular Formula: C15H19Cl2NO4

    Molecular Weight: 348.22

    MDL Number: MFCD01861044

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    Boc-(S)-3-Amino-4-(2,4-dichlorophenyl)butanoic acid is a chiral, non-natural amino acid derivative. Its structure features a Boc-protected primary amine group, a carboxylic acid group, and a 2,4-dichlorophenyl side chain, providing multiple handles for further chemical modification. The molecule is a single enantiomer, which is crucial for applications in asymmetric synthesis. This compound is primarily utilized as a key chiral building block in pharmaceutical research and development. It serves as a critical intermediate in the synthesis of complex bioactive molecules, particularly in the construction of peptide mimetics and small molecule drug candidates. The presence of the dichlorophenyl moiety suggests potential targeting of specific biological pathways, making it valuable for medicinal chemistry programs focused on creating novel therapeutic agents. As a protected amino acid derivative, it offers advantages in solid-phase peptide synthesis (SPPS) and solution-phase coupling reactions. The Boc protecting group can be selectively removed under mild acidic conditions, allowing for sequential chain elongation. Its well-defined chiral center ensures the stereochemical integrity of the final target molecules, which is often essential for their biological activity and pharmacokinetic properties.
    Physical Properties

    Boiling Point: 492.948 °C at 760 mmHg

    Flash Point: 251.926 °C

    Density: 1.294 g/cm3

    mg g kg ml l t