Boc-(S)-3-Amino-4-(2-methylphenyl)butanoic acid, CAS No. 270062-90-3

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270062-90-3

Catalog No. EBD42788

CAS 270062-90-3

Name Boc-(S)-3-Amino-4-(2-methylphenyl)butanoic acid

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Basic Information

Synonyms: Boc-(S)-3-amino-4-(2-methyl-phenyl)-butyricacid Boc-L-3-Amino-4-(2-methylphenyl)-butyricacid (3S)-3-[(tert-butoxycarbonyl)amino]-4-(2-methylphenyl)butanoicacid Boc-β-HoPhe(2-Me)-OH (S)-N-(tert-Butoxycarbonyl)-3-amino-4-(2-methylphenyl)butanoicacid Boc-(S)-3-Amino-4-(2-methylphenyl)butanoicacid

Molecular Formula: C16H23NO4

Molecular Weight: 293.36

MDL Number: MFCD01861020

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Boc-(S)-3-Amino-4-(2-methylphenyl)butanoic acid is a chiral, non-natural amino acid derivative. Its structure features a Boc-protected primary amine group, a carboxylic acid group, and a 2-methylphenyl side chain, making it a versatile building block for the synthesis of peptide mimetics and other bioactive molecules. This compound is primarily used as a key intermediate in pharmaceutical research and development. It serves as a crucial chiral synthon for constructing peptidomimetics and small molecule drug candidates, particularly those targeting proteases or other enzymes where the incorporation of a hydrophobic, aromatic side chain is desired. The Boc protecting group allows for selective deprotection and further functionalization under mild acidic conditions. As a protected amino acid derivative, it is a valuable reagent in solid-phase peptide synthesis (SPPS) and medicinal chemistry. Its application extends to the exploration of structure-activity relationships (SAR) in drug discovery programs.

Physical Properties

Boiling Point: 460.395 °C at 760 mmHg

Flash Point: 232.239 °C

Density: 1.122 g/cm3