(R)-3-Amino-4-(o-tolyl)butanoic acid hydrochloride, CAS No. 269398-79-0

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269398-79-0

Catalog No. EBD6357

CAS 269398-79-0

Name (R)-3-Amino-4-(o-tolyl)butanoic acid hydrochloride

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Basic Information

Synonyms: (R)-3-amino-4-(2-methyl-phenyl)-butyricacid-HCl D-3-Amino-4-(2-methylphenyl)-butyricacidhydrochloride Benzenebutanoicacid,β-amino-2-methyl-,(betaR)-,hydrochloride(1:1) H-D-β-HoPhe(2-Me)-OH.HCl (R)-3-Amino-4-(2-Methylphenyl)ButanoicAcidHydrochloride (R)-3-Amino-4-(o-tolyl)butanoicacidhydrochloride

Molecular Formula: C11H16ClNO2

Molecular Weight: 229.7

MDL Number: MFCD01860921

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(R)-3-Amino-4-(o-tolyl)butanoic acid hydrochloride is a chiral amino acid derivative featuring a 2-methylphenyl (o-tolyl) substituent. It is a white to off-white crystalline powder and serves as a key chiral building block in pharmaceutical synthesis. This compound is primarily recognized as a crucial intermediate in the synthesis of (R)-Baclofen, a selective GABA_B receptor agonist used as a muscle relaxant and antispastic agent for treating conditions like multiple sclerosis and spinal cord injuries. The (R)-enantiomer is the pharmacologically active form of Baclofen. Its synthesis and availability are therefore directly tied to the production of this important central nervous system (CNS) drug. As a pharmaceutically relevant chiral intermediate, it is typically handled under controlled conditions in R&D and manufacturing settings focused on CNS-active compounds. Its specific structural motif makes it less common as a general-purpose synthetic building block outside of this targeted application.

Physical Properties

Boiling Point: 377.3°C at 760 mmHg

Flash Point: 182°C