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    269396-56-7

    Catalog No. EBD48465

    CAS 269396-56-7

    Name Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)butyric acid

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    Basic Information

    Synonyms: Boc-(R)-3-amino-4-(3,4-dichlorophenyl)butyricacid Boc-(R)-3-amino-4-(3,4-dichloro-phenyl)-butyricacid (3R)-3-[(tert-butoxycarbonyl)amino]-4-(3,4-dichlorophenyl)butanoicacid Boc-D-β-HoPhe(3,4-DiCl)-OH Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)butyricacid

    Molecular Formula: C15H19Cl2NO4

    Molecular Weight: 348.22

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    Boc-(R)-3-Amino-4-(3,4-dichlorophenyl)butyric acid is a chiral, Boc-protected amino acid derivative. It serves as a crucial synthetic intermediate in the preparation of various pharmaceutical compounds. Its structure features a (R)-configured stereocenter, a 3,4-dichlorophenyl group, and a carboxylic acid functionality, making it a versatile building block for medicinal chemistry. This compound is primarily employed in the synthesis of active pharmaceutical ingredients (APIs) targeting the central nervous system. It is a key intermediate in the production of (R)-Baclofen, a selective GABAB receptor agonist used as a muscle relaxant and antispastic agent. The Boc-protected amine allows for selective deprotection and further functionalization during the synthetic route to the final drug molecule. As a high-purity chiral intermediate, it is essential for ensuring the stereochemical integrity of the final therapeutic agent. Its use is confined to research, development, and manufacturing processes within the pharmaceutical industry.
    Physical Properties

    Boiling Point: 494.798 °C at 760 mmHg

    Flash Point: 253.045 °C

    Density: 1.294 g/cm3

    mg g kg ml l t