(S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z)-2-butenedioate, CAS No. 26921-17-5

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26921-17-5

Catalog No. EBD233721

CAS 26921-17-5

Name (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z)-2-butenedioate

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Basic Information

Synonyms: (S)-Timololmaleate (S)-[1-(1,1dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanolmaleate (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol(2Z)-but-2-enedioate(salt) (2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol(2Z)-but-2-enedioate(salt) (2R)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol(Z)-2-butenedioate (S)-(-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy]-2-propanolmaleate(1:1)salt (S)-(-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thidiazol-3-yl)oxy]-2-propanolmaleatesalt timololhydrogenmaleate timololmaleate Blocanol timoptol

Molecular Formula: C17H28N4O7S

Molecular Weight: 432.49

MDL Number: MFCD00058356

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(S)-Timolol maleate is the maleate salt of the (S)-enantiomer of timolol. It is a potent, non-selective beta-adrenergic receptor antagonist (beta-blocker). The (S)-enantiomer is the pharmacologically active form, responsible for the drug's therapeutic effects. Its primary and most significant application is as an active pharmaceutical ingredient (API) in ophthalmic solutions for the treatment of elevated intraocular pressure (IOP) in conditions such as glaucoma and ocular hypertension. By blocking beta-adrenergic receptors in the ciliary body, it reduces the production of aqueous humor. Additionally, it is used systemically as an oral medication for the management of hypertension (high blood pressure) and for the secondary prevention of myocardial infarction (heart attack), making it a key drug in cardiovascular therapy. The compound is typically not used as a general-purpose synthetic building block in research chemistry. Its synthesis and handling are directed towards pharmaceutical manufacturing under Good Manufacturing Practice (GMP) standards to ensure purity and efficacy for medicinal use.

Physical Properties

Color: white to off-white

Melting Point: 202-203 °C(lit.)

Boiling Point: 487.2 °C at 760 mmHg

Flash Point: 248.5 °C

Solubility: H<SUB>2</SUB>O: soluble