(R)-(N-benzyloxycarbonyl)-p-hydroxyphenylglycine is a chiral, non-proteinogenic amino acid derivative. Its structure features a D-configuration (R-enantiomer) at the alpha carbon, a p-hydroxyphenyl side chain, and an N-terminal benzyloxycarbonyl (Cbz) protecting group. This combination makes it a valuable, optically pure building block. This compound is primarily employed as a key chiral intermediate in the synthesis of pharmaceuticals, particularly β-lactam antibiotics. Its most notable application is in the industrial production of semi-synthetic penicillins and cephalosporins, such as amoxicillin. The chiral integrity of the D-2-(4-hydroxyphenyl)glycine moiety is crucial for the biological activity of these antibiotics. The Cbz group serves to protect the amine functionality during synthetic steps, allowing for selective reactions. As a specialty fine chemical, it is produced on a commercial scale to meet the demands of the antibiotic manufacturing industry. Its synthesis and supply are critical for ensuring the availability of broad-spectrum antibacterial agents.