aspartic acid, 2-tert-butyl, ±-methyl ester hydrochloride, CAS No. 2673-19-0

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2673-19-0

Catalog No. EBD46158

CAS 2673-19-0

Name aspartic acid, 2-tert-butyl, ±-methyl ester hydrochloride

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Basic Information

Synonyms: H-Asp(OtBu)-OMe.HCl H-Asp(OBut)-OMe*HCl L-Asparticacid4-tert-butyl1-methylesterhydrochloride L-(b-O-tert-Bu)-Asp-O-Me methyltert-butyl(2R)-2-aminobutanedioatehydrochloride H-Asp(Otbu)-OmeHcl H-Asp(OtBu)-OMe·HCl asparticacid,2-tert-butyl,±-methylesterhydrochloride L-asparticacid2-t-butyl±-methylesterhydrochloride (S)(-)-2-t-butylasparticacidmethylesterhydrochloride L-aspartate-3-tert-butylesterhydrochloride L-asparticacid2-(tert-butylester)±-methylesterhydrochloride asparticacid(otbu)-omehcl h-asp(otbu)-omehydrochloride h-asp(obut)-omehcl l-asparticacidbeta-t-butylesteralpha-methylesterhydrochloride l-asparticacidbeta-t-butyl,alpha-methyl-diesterhydrochloride l-asparticacidbeta-t-butylalpha-methylesterhydrochloride l-asparticacidbeta-t-butylalpha-methylesterhydrochloridesalt H-Asp(OtBu)-OMe L-asparticacid2-t-butyl±-methylesterh

Molecular Formula: C9H18ClNO4

Molecular Weight: 239.7

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-Aspartic acid α-methyl ester β-tert-butyl ester hydrochloride is a protected derivative of the natural amino acid L-aspartic acid. It features specific protecting groups: a methyl ester at the α-carboxyl group and a tert-butyl ester at the β-carboxyl group, with the hydrochloride salt of the α-amino group. This configuration makes it a valuable chiral building block in synthetic chemistry. Its primary application is as a key intermediate in the pharmaceutical synthesis of peptides and peptidomimetics. The orthogonal protecting groups allow for selective deprotection and further functionalization, which is crucial for constructing complex molecules. It is particularly important in the synthesis of aspartame analogs and other bioactive compounds where the aspartic acid moiety needs to be incorporated with precise stereochemistry and side-chain control. This compound is a staple in medicinal chemistry research and process development for drugs targeting various diseases. It is handled as a solid and requires storage under cool, dry conditions.

Physical Properties

Boiling Point: 301.1 °C at 760mmHg

Flash Point: 135.9 °C