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    267225-27-4

    Catalog No. EBD27005

    CAS 267225-27-4

    Name (R)-2-Amino-3-(2-bromophenyl)propanoic acid

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    Basic Information

    Synonyms: D-2-Bromophe D-2-Bromophenylalanine (2R)-2-ammonio-3-(2-bromophenyl)propanoate 2-Bromo-D-phenylalanine H-D-Phe(2-Br)-OH (R)-2-Amino-3-(2-bromophenyl)propanoicacid

    Molecular Formula: C9H10BrNO2

    Molecular Weight: 244.09

    MDL Number: MFCD03092959

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    D-2-Bromophenylalanine is a non-natural, chiral amino acid derivative characterized by a bromine substituent at the ortho position of the phenyl ring attached to the D-alanine backbone. It serves as a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the preparation of peptide-based drugs and bioactive molecules. The presence of the ortho-bromine atom on the aromatic ring makes it a versatile handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Heck), enabling the rapid diversification of molecular structures during drug discovery and development. The D-configuration is particularly valuable for constructing peptides with specific stereochemistry to modulate biological activity, stability, and pharmacokinetic properties. This compound is a specialty chemical used predominantly in research and development for creating novel therapeutic agents, including enzyme inhibitors and receptor modulators.
    Physical Properties

    Boiling Point: 363.2 °C at 760 mmHg

    Flash Point: 173.4 °C

    Density: 1.588g/cm3

    Storage: Store at -15°C

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