Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    262857-90-9

    Catalog No. EBD2216396

    CAS 262857-90-9

    Name (R)-4-(4-Aminobenzyl)oxazolidin-2-one

    Get Quote
    Basic Information

    Synonyms: (R)-4-(4-Aminobenzyl)oxazolidin-2-one 2-Oxazolidinone,4-[(4-aminophenyl)methyl]-,(4R)-

    Molecular Formula: C10H12N2O2

    Molecular Weight: 192.21

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    (R)-4-(4-Aminobenzyl)oxazolidin-2-one is a chiral oxazolidinone derivative featuring a 4-aminobenzyl substituent at the 4-position. It is a white to off-white crystalline powder with a molecular formula of C10H12N2O2. The compound is characterized by its (R)-configuration at the stereogenic center, making it a valuable chiral building block. This compound serves as a key chiral intermediate in the synthesis of various pharmaceutical agents. Its primary and well-documented application is in the production of the anticoagulant drug Rivaroxaban (Xarelto®), a direct Factor Xa inhibitor. The (R)-oxazolidinone core is integral to the final drug's structure, and this specific enantiomer is crucial for achieving the desired biological activity and pharmacological profile. The synthesis and supply of high-purity (R)-4-(4-Aminobenzyl)oxazolidin-2-one are critical for the pharmaceutical industry, particularly for manufacturers of Rivaroxaban. Its role underscores the importance of chiral intermediates in modern asymmetric drug synthesis to ensure drug efficacy and safety.
    Physical Properties
    mg g kg ml l t