(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidine carboxylic acid, CAS No. 26250-84-0

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26250-84-0

Catalog No. EBD2204056

CAS 26250-84-0

Name (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidine carboxylic acid

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Basic Information

Synonyms: N-Boc-2-piperidinecarboxylicacid (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylicacid N-boc-L-pipecolinicacid Boc-Homopro-OH Boc-homoproline (S)-1-Boc-piperidine-2-carboxylicacid Boc-Pip-OH 1-(tert-Butoxycarbonyl)-L-pipecolinicacid~(S)-Piperidine-1,2-dicarboxylicacid1-tert-butylester Boc-L-Pipecolicacid BOC-(L)-Pipecolicacid (2S)-1-(tert-butoxycarbonyl)piperidine-2-carboxylicacid Boc-HoPro-OH (S)-N-BOC-Piperidine-2-carboxylicacid

Molecular Formula: C11H19NO4

Molecular Weight: 229.27

MDL Number: MFCD00151904

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-N-Boc-2-piperidinecarboxylic acid is a chiral, protected amino acid derivative. It features a piperidine ring, a carboxylic acid group, and a tert-butoxycarbonyl (Boc) protecting group on the nitrogen atom. The compound is characterized by its specific (S)-configuration at the chiral center. This compound is primarily employed as a key chiral building block and intermediate in pharmaceutical research and development. Its structure makes it valuable for the synthesis of various bioactive molecules, particularly those containing constrained, chiral amino acid motifs. It is frequently used in the construction of peptidomimetics and other drug candidates where the piperidine scaffold is a common pharmacophore, often found in compounds targeting the central nervous system, proteases, or other biological targets. As a Boc-protected amino acid, it offers orthogonal protection strategies in multi-step organic synthesis, allowing for selective deprotection and further functionalization. It is a commercially available, high-purity reagent commonly sourced for medicinal chemistry and process chemistry applications.

Physical Properties

Melting Point: 122-126 °C(lit.)

Boiling Point: 353.2 °C at 760 mmHg

Flash Point: 167.4 °C

Density: 1.164 g/cm3

Storage: Store at RT.

Analytical Data

Appearance: white to light yellow crystal powder