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    262423-77-8

    Catalog No. EBD16411

    CAS 262423-77-8

    Name 2,4-dichloronicotinic acid

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    Basic Information

    Synonyms: 2,4-Dichloropyridine-3-carboxylicacid 2,4-Dichloronicotinicacid dichloronicotinicacid 2,4-dichloro-3-pyridinecarboxylicacid 2,4-dichloropyridine-2-carboxylicacid 2,4-Dichloro-nicotinicacid 2.4-dichloronicotinicAcid

    Molecular Formula: C6H3Cl2NO2

    Molecular Weight: 192.0

    MDL Number: MFCD06796292

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    2,4-Dichloronicotinic acid is a heterocyclic aromatic compound featuring a pyridine ring substituted with chlorine atoms at the 2- and 4-positions and a carboxylic acid group at the 3-position. It is a white to off-white crystalline powder. This compound is primarily utilized as a key pharmaceutical intermediate. It serves as a crucial building block in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. For instance, it is a core fragment in the synthesis of certain antipsychotic and antidepressant drugs, where the dichloronicotinic acid scaffold is incorporated to modulate biological activity and receptor binding affinity. In addition to its pharmaceutical applications, 2,4-dichloronicotinic acid is a versatile synthetic building block in organic chemistry. The carboxylic acid group allows for further derivatization into amides, esters, or other functional groups, while the chlorine atoms provide handles for cross-coupling reactions, making it valuable for constructing more complex heterocyclic systems in medicinal chemistry research.
    Physical Properties

    Melting Point: 151-156 °C

    Boiling Point: 325.17 °C at 760 mmHg

    Flash Point: 150.458 °C

    Density: 1.612 g/cm3

    mg g kg ml l t