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    26081-03-8

    Catalog No. EBD2321970

    CAS 26081-03-8

    Name R-3-Aminohexahydro-2H-azepin-2-onehydrochloride

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    Basic Information

    Synonyms: R-3-Aminohexahydro-2H-azepin-2-onehydrochloride 2H-Azepin-2-one,3-aminohexahydro-,monohydrochloride,(3R)- (R)-3-aminoazepan-2-onehydrochloride (3R)-3-Aminohexahydro-2H-Azepin-2-OneMonohydrochloride

    Molecular Formula: C6H13ClN2O

    Molecular Weight: 164.63

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    R-3-Amino-2-caprolactam hydrochloride is a chiral, heterocyclic organic compound featuring a lactam ring structure. It is a key intermediate in the synthesis of Brivaracetam, a second-generation antiepileptic drug (AED) approved for the adjunctive treatment of partial-onset seizures. Brivaracetam is a high-affinity synaptic vesicle protein 2A (SV2A) ligand, and the R-enantiomer of this intermediate is crucial for constructing the molecule's active stereochemistry. The primary industrial application of this compound is as a critical building block in the multi-step synthesis of Brivaracetam's active pharmaceutical ingredient (API). Its production and supply are directly tied to the manufacturing of this specific neurological medication. The compound's value lies in its defined stereochemistry, which is essential for the final drug's pharmacological activity and safety profile. As a specialized pharmaceutical intermediate, its handling requires appropriate safety precautions typical of fine chemicals. Its synthesis and use are confined to advanced pharmaceutical production and research settings focused on developing or manufacturing SV2A-targeting therapies.
    Physical Properties
    mg g kg ml l t