D-Luciferin, CAS No. 2591-17-5

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2591-17-5

Catalog No. EBD54484

CAS 2591-17-5

Name D-Luciferin

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Basic Information

Synonyms: (2E,4S)-2-(6-oxo-1,3-benzothiazol-2(6H)-ylidene)-1,3-thiazolidine-4-carboxylicacid 2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylicacid (S)-4,5-dihydro-2-(6-hydroxybenzothiazol-2-yl)thiazole-4-carboxylicacid (2Z,4S)-2-(6-oxo-1,3-benzothiazol-2(6H)-ylidene)-1,3-thiazolidine-4-carboxylicacid D-Luciferin 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxy 4,5-dihydro-2-[6-hydroxy-2-benzothiazolyl]-4-thiazole-carboxylicacid 4,5-dihydro-(6-hydroxy-2-benzothiazoyl)-4-thiazolecarboxylicacid luciferin,d- luciferin d(-)-2-(6'-hydroxy-benzothiazolyl)-delta2-thiazoline-4-carboxylicacid d(-)-luciferin brightglo d-(-)-luciferin beetleluciferin fireflyluciferin luciferin(firefly)

Molecular Formula: C11H8N2O3S2

Molecular Weight: 280.32

MDL Number: MFCD00042929

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > In Vivo Research Reagents Medicinal Chemistry > Biochemicals and Life Science Reagents > Fluorescent Probes and Labeling Reagents

Product Description:

D-Luciferin is a heterocyclic carboxylic acid and the natural substrate for the enzyme luciferase, derived from the firefly *Photinus pyralis*. It is a key component in bioluminescence imaging (BLI) technology. Its primary application is as an injectable reagent for in vivo and in vitro bioluminescence assays. Upon administration and in the presence of ATP, Mg²⁺, and oxygen, D-luciferin is catalyzed by luciferase to produce oxyluciferin and emit visible light (~560 nm). This property makes it indispensable for non-invasive, real-time monitoring of biological processes in living animals, widely used in oncology research (e.g., tracking tumor growth and metastasis), gene expression studies, drug efficacy evaluation, and stem cell research. D-Luciferin is also utilized as a highly sensitive and quantitative reporter molecule in cell-based assays, high-throughput screening (HTS), and molecular biology. Its potassium salt form is commonly used to improve aqueous solubility for in vivo applications.

Physical Properties

Melting Point: 200-204 °C

Boiling Point: 587.579 °C at 760 mmHg

Flash Point: 309.157 °C

Density: 1.815 g/cm3

Storage: −20°C

Analytical Data

Appearance: off-white to light yellow powder