4-Amino-2,6-dichloropyridine, CAS No. 2587-02-2

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2587-02-2

Catalog No. EBD26751

CAS 2587-02-2

Name 4-Amino-2,6-dichloropyridine

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Basic Information

Synonyms: 4-Pyridinamine,2,6-dichloro- 4-amino-2,6-dichloropyridinium 2,6-Dichloro-pyridin-4-ylamine 2,6-Dichloro-4-aminopyridine 2,6-Dichloropyridin-4-amine 4-Amino-2,6-dichloropyridine auroraka-3022 2,6-dichloro-4-pyridinamine 2,6-dichloropyridine-4-amine

Molecular Formula: C5H4Cl2N2

Molecular Weight: 163.0

MDL Number: MFCD00052832

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

4-Amino-2,6-dichloropyridine is an organic compound featuring a pyridine ring substituted with an amino group at the 4-position and chlorine atoms at the 2- and 6-positions. This structure makes it a versatile and valuable heterocyclic building block in organic synthesis. Its primary application is as a key intermediate in the pharmaceutical industry. It serves as a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates. For example, it is a documented intermediate in the synthesis of the anti-inflammatory drug Tenidap and other biologically active molecules targeting inflammation and pain. The presence of both an amino group and two chlorine atoms allows for selective functionalization, enabling the construction of complex molecular architectures. As a bifunctional synthon, it is widely used in research and development for constructing pyridine-based scaffolds. Its reactivity is leveraged in nucleophilic aromatic substitution reactions and metal-catalyzed cross-couplings, making it a common starting material in medicinal chemistry and material science explorations.

Physical Properties

Melting Point: 169-173 °C(lit.)

Boiling Point: 336.7 °C at 760 mmHg

Flash Point: 157.4 °C

Density: 1.497 g/cm3