(2S,4R)-methyl 1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate, CAS No. 254882-06-9

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254882-06-9

Catalog No. EBD303920

CAS 254882-06-9

Name (2S,4R)-methyl 1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate

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Basic Information

Synonyms: 1-tert-butyl2-methyl4-hydroxypiperidine-1,2-dicarboxylate (2S,4R)-methyl1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate N-Boccis4R-hydroxy-2S-pipecolicacidmethylester (rac,cis)-4-hydroxy-piperidine-1,2-dicarboxylicacid1-tert-butylester2-methylester (2S,4R)-4-hydroxy-piperidine-1,2-dicarboxylicacid1-tert-butylester2-methylester (2S,4R)-N-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylicacidmethylester (2S,4R)-N-BOC-4-Hydroxypiperidine-2-carboxylicacidmethylester Methyl(2S,4R)-N-BOC-4-hydroxypiperidine-2-carboxylate

Molecular Formula: C12H21NO5

Molecular Weight: 259.3

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

Product Description:

(2S,4R)-Methyl 1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate is a chiral piperidine derivative characterized by a tert-butoxycarbonyl (Boc) protecting group on the nitrogen, a methyl ester, and a hydroxyl group at the 4-position. Its defined stereochemistry at the 2 and 4 positions makes it a valuable non-racemic building block. This compound is primarily employed as a key chiral intermediate in pharmaceutical synthesis. Its structure serves as a crucial scaffold for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and drug candidates. The presence of multiple functional groups allows for selective modifications, enabling its incorporation into target structures requiring a substituted piperidine moiety. As a specialty intermediate, it is not considered a general-purpose synthetic reagent. Its primary commercial and research value lies in its application within medicinal chemistry for the synthesis of potential therapeutics, rather than in broad organic synthesis or material science contexts.

Physical Properties

Boiling Point: 352.1°Cat760mmHg

Flash Point: 166.8°C

Density: 1.182g/cm3