4-Chloro-3-fluoropyridine, CAS No. 2546-56-7

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2546-56-7

Catalog No. EBD29683

CAS 2546-56-7

Name 4-Chloro-3-fluoropyridine

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Basic Information

Synonyms: 4-Chlor-3-fluorpyridin Pyridine,4-chloro-3-fluoro- 3-fluoro-4-chloropyridine 2-methyl-4-chloropyridinehydrochloride 4-chloro-3-fluoropyridine4-chloro-3-fluoropyridine chlorofluoropyridine43--- 4-chloro-3-fluoropyridine>=95.0% 4-Chloro-3-fluoropyridine

Molecular Formula: C5H3ClFN

Molecular Weight: 131.54

MDL Number: MFCD03453233

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

4-Chloro-3-fluoropyridine is a heterocyclic building block featuring a pyridine ring substituted with chlorine at the 4-position and fluorine at the 3-position. This compound is a key intermediate in pharmaceutical and agrochemical synthesis, primarily used to construct biologically active molecules. The presence of both halogen atoms allows for selective cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, enabling the introduction of diverse functional groups. It is commonly employed in the development of kinase inhibitors, antiviral agents, and other drug candidates targeting the central nervous system or oncology. As a versatile synthetic building block, it also serves as a precursor for advanced materials and ligands.

Physical Properties

Boiling Point: 138.9 °C at 760 mmHg

Flash Point: 28 °C

Density: 1.333 g/mL at 25 °C(lit.)

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 1993C

Analytical Data

Appearance: Light yellow liquid