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    253595-72-1

    Catalog No. EBD2206567

    CAS 253595-72-1

    Name Z-N-Me-Thr-OH·CHA

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    Basic Information

    Synonyms: L-Threonine,N-methyl-N-[(phenylmethoxy)carbonyl]- Z-N-Me-Thr-OH·CHA Z-N-ME-THR-OH Z-N-ME-THR-OHCHA Z-L-METHR-OH Z-N-METHYL-L-THREONINE Z-N-MET-THR-OHCHA N-ALPHA-BENZYLOXYCARBONYL-N-ALPHA-METHYL-L-THREONINE

    Molecular Formula: C13H17NO5

    Molecular Weight: 267.28

    MDL Number: MFCD02259506

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

    Product Description:
    Z-N-Me-Thr-OH·CHA, with the CAS number 253595-72-1, is a chemical compound consisting of N-methyl-L-threonine protected at the N-terminus with a benzyloxycarbonyl (Z or Cbz) group and isolated as a cyclohexylammonium (CHA) salt. This specific salt form enhances the compound's stability and crystallinity, making it more suitable for handling and storage in synthetic applications. This compound is primarily utilized as a chiral, protected amino acid derivative in peptide synthesis, particularly in the pharmaceutical industry. The N-methylation of the amino acid backbone is a critical modification that can significantly alter the biological and pharmacokinetic properties of the resulting peptides, such as improving metabolic stability, membrane permeability, and bioavailability. Therefore, Z-N-Me-Thr-OH·CHA serves as a crucial building block for the synthesis of complex peptide-based drugs and bioactive peptides. As a derivative of the proteinogenic amino acid threonine, it falls under the category of modified amino acids. Its primary value lies in its role as a specialized, non-natural amino acid synthon for constructing peptides with tailored properties, making it a key reagent in medicinal chemistry and peptide research.
    Physical Properties
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