4-Morpholinoaniline, CAS No. 2524-67-6

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2524-67-6

Catalog No. EBD8869

CAS 2524-67-6

Name 4-Morpholinoaniline

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Basic Information

Synonyms: Benzenamine,4-(4-morpholinyl)- 4-(morpholin-4-yl)aniline N-(4-aminophenyl)morpholine 4-(4-Morpholinyl)-benzenamin asischemz37706 art-chem-bbb025582 labotest-bblt00083657 akosb025582 akosbb-8569 akosbbs-00006991 4-morpholinophenylamine 4-Morpholinoaniline 4-(4-morpholinyl)aniline (4-(morpholino)phenyl)amine 4-(4-aminophenyl)morpholine 4-(4-morpholinyl)benzenamine 4-(morpholin-4-yl)phenylamine

Molecular Formula: C10H14N2O

Molecular Weight: 178.23

MDL Number: MFCD00006169

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

4-Morpholino-3-nitroaniline is an organic compound featuring both a morpholine ring and a nitro-substituted aniline structure. It serves as a versatile chemical intermediate in pharmaceutical research and development. Its primary application is as a key building block in the synthesis of various biologically active molecules. The compound has been specifically cited in patents and research literature for the preparation of kinase inhibitors, particularly those targeting the PI3K/Akt/mTOR signaling pathway, which is crucial in oncology for developing anti-cancer therapeutics. The morpholine and nitroaniline moieties are valuable pharmacophores that contribute to the binding affinity and selectivity of the final drug candidates. As an amine-containing aromatic nitro compound, it is also a useful substrate in organic synthesis for further functionalization, such as reduction of the nitro group to an amine or participation in coupling reactions.

Physical Properties

Melting Point: 132-135 °C(lit.)

Boiling Point: 368 °C at 760 mmHg

Flash Point: 176.4 °C

Density: 1.149 g/cm3

Analytical Data

Appearance: purple to brown crystalline powder