(R)-3-piperidine-carboxylic acid ethyl ester, CAS No. 25137-01-3

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25137-01-3

Catalog No. EBD2199718

CAS 25137-01-3

Name (R)-3-piperidine-carboxylic acid ethyl ester

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Basic Information

Synonyms: (R)-3-piperidine-carboxylicacidethylester (R)-Piperidine-3-carboxylicacidethylester 3-piperidinecarboxylicacid,ethylester,(3R)- Ethyl(3R)-piperidine-3-carboxylate (3R)-(-)-Ethylnipecotate (R)-NipecoticAcidEthylEster (R)-Ethylpiperidine-3-carboxylate

Molecular Formula: C8H15NO2

Molecular Weight: 157.21

MDL Number: MFCD03093637

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-3-Piperidinecarboxylic acid ethyl ester is a chiral organic compound featuring a piperidine ring substituted with an ethyl ester group at the 3-position. It is a versatile chiral building block, particularly valued for its (R)-configuration. Its primary application is as a key chiral intermediate in the pharmaceutical industry. It is extensively used in the synthesis of various active pharmaceutical ingredients (APIs), especially those targeting the central nervous system. For instance, it serves as a crucial precursor in the production of (R)-3-Piperidinecarboxylic acid, which is further utilized in the synthesis of important drugs like carfentanil and other potent analgesics or receptor modulators. The compound is commercially available from fine chemical suppliers for research and development purposes. As with many pharmaceutical intermediates, it requires careful handling, and appropriate safety data sheets (SDS) should be consulted for specific hazard and storage information.

Physical Properties

Boiling Point: 110 °C / 20mmHg

Flash Point: 104 °C

Density: 1.092 g/mL at 25 °C

Refractivity: -1.5 ° (C=neat)

Storage: Refrigerator

Analytical Data

Appearance: Light yellow liquid