(S)-2-Acetamido-3-(1H-imidazol-4-yl)propanoic acid, CAS No. 2497-02-1

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2497-02-1

Catalog No. EBD90453

CAS 2497-02-1

Name (S)-2-Acetamido-3-(1H-imidazol-4-yl)propanoic acid

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Basic Information

Synonyms: ac-his-ohh2o acetyl-l-histidineh2o acetyl-l-histidinemonohydrate n-alpha-acetyl-l-histidineh2o n-alpha-acetyl-l-histidinehydrate n-alpha-acetyl-l-histidinemonohydrate n-acetyl-l-histidine n-acetyl-l-histidinehydrate Acetylhistidine N-acetylhistidine (S)-2-Acetamido-3-(1H-imidazol-4-yl)propanoicacid

Molecular Formula: C8H11N3O3

Molecular Weight: 197.19

MDL Number: MFCD00005206

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Acetyl-L-histidine is a derivative of the essential amino acid L-histidine, where the amino group is acetylated. It is a white to off-white crystalline powder with a molecular formula of C8H11N3O3. This compound is a chiral molecule and is typically available in its L-configuration. Its primary applications are in the fields of biochemistry, life sciences, and pharmaceutical research. It serves as a key biochemical reagent and a building block for peptide synthesis. Notably, N-Acetyl-L-histidine has been investigated for its potential neuroprotective and osmoregulatory roles. It is found at high concentrations in the lenses of certain fish and vertebrate eyes, where it is believed to act as a molecular water pump and an antioxidant, protecting proteins from aggregation. This has spurred research into its potential therapeutic use for cataracts and other eye disorders. As a protected amino acid derivative, it is also utilized in organic synthesis as a specialized chiral synthon. It must be stored in a cool, dry place, and standard laboratory safety precautions should be observed when handling fine chemical powders.

Physical Properties

Melting Point: 157-159 °C

Boiling Point: 620.2 °C at 760mmHg

Flash Point: 328.9 °C

Density: 1.366g/cm3