2-Bromo-4\'-hydroxyacetophenone, CAS No. 2491-38-5

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2491-38-5

Catalog No. EBD54271

CAS 2491-38-5

Name 2-Bromo-4\'-hydroxyacetophenone

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Basic Information

Synonyms: 2-Bromo-4\'-hydroxyacetophenone alpha-Bromo-4-Hydroxyacetophenone 2-Bromo-4'-HydroxyAcetophenone α-Bromo-4-HydroxyAcetophenone α-Bromo-1-(4-hydroxyphenyl)-ethanone Ethanone,2-bromo-1-(4-hydroxyphenyl)- α-bromo-hydroxyacetophenone 2-bromo-1-(4-hydroxyphenyl)ethanone ptpinhibitori proteintyrosinephosphataseinhibitori 4-hydroxyphenacylbr 4-hydroxyphenacylbromide 2-bromo-1-(4-hydroxy-phenyl)-ethanone 2'-bromo-4'-hydroxyacetophenone

Molecular Formula: C8H7BrO2

Molecular Weight: 215.04

MDL Number: MFCD00072424

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

Α-Bromo-4-hydroxyacetophenone is an organic compound featuring a bromomethyl ketone group adjacent to a phenolic hydroxyl group. It is a white to off-white crystalline powder with a molecular formula of C8H7BrO2. This structure makes it a versatile and reactive synthetic building block. Its primary and most significant application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various heterocyclic compounds, particularly in the production of cardiovascular drugs. For instance, it is a vital starting material for the synthesis of Atenolol, a widely used beta-blocker for treating hypertension and angina. The reactive α-bromo ketone moiety readily undergoes nucleophilic substitution and cyclization reactions, enabling the construction of complex molecular scaffolds found in active pharmaceutical ingredients (APIs). Beyond its role in drug synthesis, this compound is also utilized in organic chemistry research as a reagent for introducing the bromoacetyl functional group. It finds use in the preparation of other fine chemicals and as a cross-linking agent in some polymer applications. Due to its lachrymatory and irritant properties, appropriate safety precautions are required during handling.

Physical Properties

Boiling Point: 338.7 °C at 760 mmHg

Flash Point: 158.6 °C

Density: 1.622 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: clear colorless to light yellow liquid