2',5'-Dichloroacetophenone, CAS No. 2476-37-1

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2476-37-1

Catalog No. EBD410

CAS 2476-37-1

Name 2',5'-Dichloroacetophenone

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Basic Information

Synonyms: 1-(2,5-Dichlorophenyl)ethanone 2',5'-Dichloroacetophenone 2,5-dichloroacetophenone 1-(2,5-dichlorophenyl)-ethanon acetophenone,2',5'-dichloro- ethanone,1-(2,5-dichlorophenyl)- 2',5'-dichloroacetophenone1-(2,5-dichlorophenyl)ethanone 1-(2,5-dichlorophenyl)ethan-1-one

Molecular Formula: C8H6Cl2O

Molecular Weight: 189.04

MDL Number: MFCD00000607

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2',5'-Dichloroacetophenone is a chlorinated aromatic ketone featuring a dichlorophenyl ring directly attached to an acetyl group. Its molecular formula is C8H6Cl2O, and it serves as a key building block in organic synthesis. This compound is primarily utilized as a pharmaceutical intermediate, particularly in the synthesis of small-molecule drug fragments. It acts as a precursor for antifungal agents (e.g., miconazole analogs) and other bioactive molecules, where the dichloro substitution pattern enhances metabolic stability and binding affinity. Additionally, it functions as a versatile synthetic building block in organic chemistry, classified under halogenated compounds. Its reactive ketone group enables further transformations such as nucleophilic addition, reduction, or condensation, making it valuable for constructing complex molecular architectures in medicinal chemistry and agrochemical research.

Physical Properties

Melting Point: 11-13 °C(lit.)

Boiling Point: 118 °C (12 mmHg)

Flash Point: >113 °C

Density: 1.312 g/mL at 25 °C(lit.)

Solubility: Insoluble in water. Solulbe in benzene and ethanol

Refractivity: n20/D 1.5624(lit.)