mono-Ethyl fumarate, CAS No. 2459-05-4

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2459-05-4

Catalog No. EBD3316691

CAS 2459-05-4

Name mono-Ethyl fumarate

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Basic Information

Synonyms: mono-Ethylfumarate Fumaricacidmonoethylester Monoethylfumarate ethylfumarate Ethylhydrogenfumarate (2E)-4-ethoxy-4-oxobut-2-enoicacid lithium(2E)-4-ethoxy-4-oxobut-2-enoate sodium(2Z)-4-ethoxy-4-oxobut-2-enoate (2E)-4-ethoxy-4-oxobut-2-enoicacid-zinc(1:1) calciumdihydride-(2E)-4-ethoxy-4-oxobut-2-enoicacid(1:1) 4-ethoxy-4-oxobut-2-enoate

Molecular Formula: C6H8O4

Molecular Weight: 144.13

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

Monoethyl fumarate is an organic compound featuring a fumaric acid core with one carboxylic acid group esterified with ethanol. It is a white to off-white crystalline powder. This compound serves as a key intermediate in the synthesis of various pharmaceutical agents. Its primary application is in the production of dimethyl fumarate and monomethyl fumarate, which are active pharmaceutical ingredients (APIs) used in the treatment of multiple sclerosis and psoriasis. The molecule itself is also investigated for its potential biological activities, including anti-inflammatory properties. As a bifunctional molecule containing both a carboxylic acid and an ester group, monoethyl fumarate is a versatile building block in organic synthesis. It is used in polymer chemistry and material science for creating cross-linked networks and functional materials.

Physical Properties

Melting Point: 66-68 °C(lit.)

Boiling Point: 147 °C/16 mmHg(lit.)

Flash Point: 109.6 °C

Density: 1.208 g/cm3

Storage: Refrigerator