(2S,4R)-1-(2-Aminoacetyl)-4-hydroxypyrrolidine-2-carboxylic acid, CAS No. 24587-32-4

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24587-32-4

Catalog No. EBD164787

CAS 24587-32-4

Name (2S,4R)-1-(2-Aminoacetyl)-4-hydroxypyrrolidine-2-carboxylic acid

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Basic Information

Synonyms: gly-hydroxy-pro Glycyl-4-hydroxyproline Gly-4-hydroxy-pro Gly-hyp NSC89599 L-Proline,1-glycyl-4-hydroxy-,trans- glycyl-4-hydroxy-L-proline H-Gly-Hyp-OH (2S,4R)-1-(2-Aminoacetyl)-4-hydroxypyrrolidine-2-carboxylicacid

Molecular Formula: C7H12N2O4

Molecular Weight: 188.18

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

(2S,4r)-1-(2-Aminoacetyl)-4-hydroxypyrrolidine-2-carboxylic acid is a heterocyclic amino acid derivative featuring a pyrrolidine ring substituted with a hydroxymethyl group at the 4-position and a carboxy group at the 2-position. The nitrogen atom of the pyrrolidine is acylated with a glycyl (aminoacetyl) moiety. This compound is a chiral building block with defined stereochemistry at the 2- and 4-positions. This molecule serves as a key intermediate in the synthesis of various pharmaceuticals and bioactive compounds. Its structure, containing both a carboxylic acid and an amine group, makes it a versatile precursor for constructing more complex molecules, particularly in the field of peptide mimetics and protease inhibitors. The hydroxymethyl group provides a handle for further chemical modifications. As a specialized chiral synthon, it is primarily used in research and development for drug discovery programs. It is not a commodity chemical and is typically supplied for laboratory use in medicinal chemistry.

Physical Properties

Boiling Point: 485.6 °C at 760 mmHg

Flash Point: 247.5 °C

Density: 1.518 g/cm3